THE CHEMICAL COMPOSITION OF THE MEDICINAL PLANT MOMORDICA CHARANTIA L USED IN FOLK MEDICINE
Keywords:
Momordica charantia L, application in folk medicine, action against diabetes mellitus, fruits, chemical compositionAbstract
The use of medicinal plants in folk medicine, the discovery of their new useful properties, of course, is directly related to their chemical composition. The medicinal plant Momordica charanthia L, studied in our study, is also known for its healing properties since ancient times, this plant, which is native to India, is grown in Asian countries. Based on the research of scientists, we have grown the plant in the climatic conditions of Uzbekistan. It is used in folk medicine due to antihyperglycemic, antibacterial, antiviral, antitumor, immunomodulatory, antioxidant activity, including antidiabetic for the treatment of diabetes mellitus. Various bioactive substances have been found in the plant, including phytochemicals such as proteins, polysaccharides, flavanoids, triterpenes, saponins, ascorbic acid and steroids. As a result of the research, the use of the plant in folk medicine was studied, and the article will also provide information about the chemical composition of the plant.
References
Villarreal-La Torre, V. E., Guarniz, W. S., Silva-Correa, C., Cruzado-Razco, L., & Siche, R. (2020). Antimicrobial activity and chemical composition of Momordica Charantia: A review. Pharmacognosy Journal, 12(1).
Rohajatien U, Harijono H, Estiasih T, Sriwahyuni E. Bitter melon (Momordica charantia L) fruit decreased blood glucose level and improved lipid profile of streptozotocin induced hyperglycemia rats. Curr Res Nutr Food Sci. 2018;6(2):359-70.
Chan FK, Hsu C, Li TC, Chen WH, Tseng KT, Chao PM. Bitter melon seed oil increases mitochondrial content in gastrocnemius muscle and improves running endurance in sedentary C57BL/6J mice. J Nutr Biochem. 2018;58:150-7.
Saeed MK, Shahzadi I, Ahmad I, Ahma R, Shahzad K, Ashraf M, et al. Nutritional analysis and antioxidant activity of bitter gourd (Momordica charantia) from Pakistan. Pharmacologyonline. 2010;1:252-60.
Zhang F, Lin L, Xie J. A mini-review of chemical and biological properties of polysaccharides from Momordica charantia. Int J Biol Macromol. 2016;92:246-53.
Patel S, Patel T, Parmar K, Bhatt Y, Patel Y, Patel NM. Isolation, characterization and antimicrobial activity of charantin from Momordica Charantia Linn. fruit. Int J Drug Dev Res. 2010;2(3):629-34.
Desai S, Tatke P. Charantin: An important lead compound from Momordica charantia for the treatment of diabetes. J Pharmacogn Phytochem. 2015;3(6):163-6.
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013;3(2):93-102.
Zhu F, Zhang P, Meng YF, Xu F, Zhang DW, Cheng J, et al. Alpha-momorcharin, a RIP produced by bitter melon, enhances defense response in tobacco plants against diverse plant viruses and shows antifungal activity in vitro. Planta. 2013;237(1):77-88.
Ching-Dong C, Ping-Yuan L, Yo-Chia C, Han-Hsiang H, Wen-Ling S. Novel purification method and antibiotic activity of recombinant Momordica charantia MAP30. 3 Biotech. 2017;7(1):3.
Wang S, Zhang Y, Liu H, He Y, Yan J, Wu Z, et al. Molecular cloning and functional analysis of a recombinant ribosome-inactivating protein (alpha-momorcharin) from Momordica charantia. Appl Microbiol Biotechnol. 2012;96(4):939-50.
Jia S, Shen M, Zhang F, Xie J. Recent advances in Momordica charantia: Functional components and biological activities. Int J Mol Sci. 2017;18(12):1-25.
Chen J, Tian R, Qiu M, Lu L, Zheng Y, Zhang Z. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry. 2008;69(4):1043-8.
Beloin N, Gbeassor M, Akpagana K, Hudson J, de Soussa K, Koumaglo K, et al. Ethnomedicinal uses of Momordica charantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity. J Ethnopharmacol. 2005;96(1-2):49-55.
Thiruvengadam M, Praveen N, Maria John KM, Yang Y-S, Kim S-H, Chung I-M. Establishment of Momordica charantia hairy root cultures for the production of phenolic compounds and determination of their biological activities. Plant Cell Tiss Organ Cult. 2014;118(3):545-57.
Swarna J, Ravindhran R. Agrobacterium rhizogenes - mediated hairy root induction of Momordica charantia Linn. and the detection of charantin, a potent hypoglycaemic agent in hairy roots. Res J Biotechnol. 2012;7(4):227-31.
Chen JC, Lu L, Zhang XM, Zhou L, Li ZR, Qiu MH. Eight new cucurbitane glycosides, kuguaglycosides A-H, from the root of Momordica charantia L. Helv Chim Acta. 2008;91(5):920-
Perez JL, Jayaprakasha GK, Patil BS. Metabolite profiling and in vitro biological activities of two commercial bitter melon (Momordica charantia Linn.) cultivars. Food Chem. 2019; 288:178-86.
Upadhyay A, Agrahari P, Singh DK. A review on salient pharmacological features of Momordica charantia. Int J Pharmacol. 2015;11(5):405-13.
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013;3(2):93-102.
Patel S, Patel T, Parmar K, Bhatt Y, Patel Y, Patel NM. Isolation, characterization and antimicrobial activity of charantin from Momordica Charantia Linn. fruit. Int J Drug Dev Res. 2010;2(3):629-34.
Perez JL, Jayaprakasha GK, Patil BS. Separation and Identification of Cucurbitane-Type Triterpenoids from Bitter Melon. In: Jayprakasha GK, Patil BS, Pellati F, editors. Instrumental Methods for the Analysis and Identification of Bioactive Molecules. Texas: American Chemical Society; 2014. p. 51-78.
Okabe H, Miyahara Y, Yamauchi T. Studies on the constituents of Momordica charantia L. III. Characterization of new cucurbitacin glycosides of the immature fruits. (1). Structures of momordicosides G, F1, F2 and I. Chem Pharm Bull. 1982;30(11):3977-86.
Okabe H, Miyahara Y, Yamauchi T. Studies on the constituents of Momordica charantia L. IV. Characterization of the new cucurbitacin glycosides of the immature fruits. (2) Structures of the bitter glycosides, momordicosides K and L. Chem Pharm Bull. 1982;30(12):4334-40.
Rohajatien U, Harijono H, Estiasih T, Sriwahyuni E. Bitter melon (Momordica charantia L) fruit decreased blood glucose level and improved lipid profile of streptozotocin induced hyperglycemia rats. Curr Res Nutr Food Sci. 2018;6(2):359-70.
Rodriguez DB, Raymundo LC, Lee T-C, Simpson KL, Chichester CO. Carotenoid pigment changes in ripening Momordica charantia fruits. Ann Bot-London. 1976;40(3):615-24.
Saini RK, Keum YS. Characterization of nutritionally important phytoconstituents in bitter melon (Momordica charantia L.) fruits by HPLC-DAD and GC-MS. J Food Meas Charact. 2017;11(1):119-25.
Deng YY, Yi Y, Zhang LF, Zhang RF, Zhang Y, Wei ZC, et al. Immunomodulatory Activity and Partial Characterisation of Polysaccharides from Momordica charantia. Molecules. 2014;19(9):13432-47.
Jia S, Shen M, Zhang F, Xie J. Recent advances in Momordica charantia: Functional components and biological activities. Int J Mol Sci. 2017;18(12):1-25.
Guarniz W, Canuto K, Ribeiro P, Dodou H, Magalhaes K, Sa K. Momordica Charantia L. variety from Northeastern Brazil: Analysis of Antimicrobial Activity and Phytochemical Components. Pharmacog J. 2019;11(6):1312-24.
Mala M, Hepsibah AH, Jothi GJ. Silver nanoparticles synthesis using Coccinia Grandis (L.) voigt and Momordica Charantia L, its characterization and biological screening. J Bionanosci. 2017;11(6):504-13.
Guevara AP, Lim-Sylianco CY, Dayrit FM, Finch P. Acylglucosyl sterols from Momordica charantia. Phytochemistry. 1989;28(6):1721-4.
Park H, Moon B, Kim S. Antioxidant and α-glucosidase inhibitory activities of fresh bitter melon and change of charantin and lutein content upon brining and blanching treatments of pickling. Korean J Food Sci Technol. 2018;50(4):430-6.
Annapoorani CA, Manimegalai K. Evaluation of biological activity and qualitative analysis of 2,5-dihydroxybenzoic acid from Momordica charantia fruit. Int J Pharm Sci Rev Res. 2013;22(2):89-95.
Cuong DM, Kwon SJ, Jeon J, Park YJ, Park JS, Park SU. Identification and characterization of phenylpropanoid biosynthetic genes and their accumulation in bitter melon (Momordica charantia). Molecules. 2018;23(2):469.
Bukhari SA, Farah N, Mustafa G, Mahmood S, Naqvi SAR. Magneto-priming improved nutraceutical potential and antimicrobial activity of Momordica charantia L. without affecting nutritive value. Appl Biochem Biotechnol. 2019;188(3):878-892.
Svobodova B, Barros L, Calhelha RC, Heleno S, Alves MJ, Walcott S, et al. Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. Ind Crop Prod. 2017; 95:365-73.
Panlilio BG, Macabeo APG, Knorn M, Kohls P, Richomme P, Kouam SF, et al. A lanostane aldehyde from Momordica charantia. Phytochem Lett. 2012;5(3):682-4.
Наумова, Н. Б., Фотев, Ю. В., Бугровская, Г. А., & Белоусов, В. П. (2015). Макро и микроэлементный состав вигны, кивано, момордики и бенинказы при тепличном выращивании. Овощи России, (3), 11-17.
Saengsai J, Kongtunjanphuk S, Yoswatthana N, Kummalue T, Jiratchariyakul W. Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine. Evid-Based Compl Alt. 2015; 2015:10 pages.
Ajitha B, Reddy YAK, Reddy PS. Biosynthesis of silver nanoparticles using Momordica charantia leaf broth: Evaluation of their innate antimicrobial and catalytic activities. J Photochem Photobiol B. 2015; 146:1-9.
Bharathi LK, John KJ. Momordica genus in Asia - An overview. Vol. 9788132210, Springer. New Delhi; 2013. 1-147 p.
Abalaka ME, Onaolapo JA, Inabo HI, Olonitola OS. Antibacterial activity of chromatographically separated pure fractions of whole plant of Momordica charantia L (Cucurbitaceae). Adv Environ Biol. 2010;4(3):509-14.
Chan FK, Hsu C, Li TC, Chen WH, Tseng KT, Chao PM. Bitter melon seed oil increases mitochondrial content in gastrocnemius muscle and improves running endurance in sedentary C57BL/6J mice. J Nutr Biochem. 2018; 58:150-7.
Ghaffar F, Kainatm B, Shah HU, Rahman IU. DPPH Radical Scavenging Assay, Biological Activities, Nutricional Composition and Quality Parameters of Momordica charantia Seeds Grown in District CHarsadda, KPK, Pakistan. Pak J Sci Ind Res Ser B Biol Sci. 2017;60(2):80-6.
Braca A, Siciliano T, D’Arrigo M, Germanò MP. Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. Fitoterapia. 2008;79(2):123-5.
Horax R, Hettiarachchy N, Islam S. Total phenolic contents and phenolic acid constituents in 4 varieties of bitter melons (Momordica charantia) and antioxidant activities of their extracts. J Food Sci. 2005;70(4):C275-80.
Popovich DG, Li L, Zhang W. Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food Chem Toxicol. 2010;48(6):1619-26.
Okabe H, Miyahara Y, Yamauchi T, Miyahara K, Kawasaki T. Studies on the constituents of Momordica charantia L. I. Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chem Pharm Bull. 1980;28(9):2753-62.
Miyahara Y, Okabe H, Yamauchi T. Studies on the constituents of Momordica charantia L. II. isolation and characterization of minor seed glycosides, momordicosides C, D and E. Chem Pharm Bull. 1981;29(6):1561-6.
Makhija M, Ahuja D, Nandy BC, Gautam S, Tiwari K, Awasthi A, et al. Evaluation and comparison of antibacterial activity of leaves, seeds and fruits extract of Momordica charantia. Res J Pharm Biol Chem Sci. 2011;2(2):185-92.
Liu R, Gupta SK, Liaw S, Chyuan J-H, Tsay H-S. In vitro studies on newly developed variety of Momordica charantia L. Hualien No. 1 and its metabolites analysis. Int J Integ Biol. 2011;11(3):155-60.
Fang EF, Ng TB. The bitter fruit with sweet health benefits: A comprehensive synopsis of recent research progress on medicinal properties of Momordica charantia. In: Fang EF, Ng TB, editors. Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Baltimore: Springer; 2013. p. 315-34.
Li SS. Purification and partial characterization of two lectins from Momordica charantia. Experientia. 1980;36(5):524-7.
Allen A. P., Gillooly J. F. Towards an integration of ecological stoichiometry and the metabolic theory of ecology to better understand nutrient cycling // Ecology Letters. "2009. "V. 12." N.5. "P.369"384.
Самадов, Б. Ш., Жалилов, Ф. С., & Жалилова, Ф. С. (2020). ВЫРАЩИВАНИЕ ЛЕКАРСТВЕННОГО РАСТЕНИЯ «MOMORDICA CHARANTIA L» В УСЛОВИЯХ БУХАРСКОЙ ОБЛАСТИ. Вестник науки и образования, (21-1), 92-98.
Дубинина, Н. В., Дубініна, Н. В., Самадов, Б. Ш., Тищенко, И. Ю., & Тіщенко, І. Ю. (2020). Перспективы использования лекарственного сырья момордика харанция для создания новых лекарственных средств.
Б.Ш. Самадов, Ф.С. Жалилова, Ф.С. Жалилов, Н.А. Муродова., Фармакологическая свойства и химический состав лекарственного растительного сырья “Momordica Charantia L”. Матеріали ІV Міжнародної науково-практичної конференції. Харків, НФаУ, 2020. С. 426-430.
Самадов, Б. Ш., Жалилова, Ф. С., Жалилов, Ф. С., & Муродова, Н. А. (2020). ФАРМАКОЛОГИЧЕСКАЯ СВОЙСТВА И ХИМИЧЕСКИЙ СОСТАВ ЛЕКАРСТВЕННОГО РАСТИТЕЛЬНОГО СЫРЬЯ “MOMOR-DICA CHARANTIA L”. Новый день в медицине. Научно-реферативный, духовно-просветительский журнал, 1, 29.
Самадов Б. Ш., Жалилова Ф. С., Жалилов Ф. С. ХИМИЧЕСКИЙ СОСТАВ ПЛОДЫ “MOMORDICA CHARANTIA L” ВЫРАЩЕННОГО В УСЛОВИЯХ БУХАРСКОЙ ОБЛАСТИ РЕСПУБЛИКИ УЗБЕКИСТАН. Матеріали IX Міжнародної науково-практичної internet-конференціі «Сучасні досягнення фармацевтичної технології». Харків, НФаУ. Редакційна колегія. – 2021. – С. 3-7.
Самадов, Б. Ш., Жалилов, Ф. С., Жалилова, Ф. С., & Шарипова Э.М. (2021). ХИМИЧЕСКИЙ СОСТАВ ЛЕКАРСТВЕННОГО СЫРЬЯ “MOMORDICA CHARANTIA L”, ВЫРАЩИВАННОГО В УСЛОВИЯХ БУХАРСКОЙ ОБЛАСТИ РЕСПУБЛИКИ УЗБЕКИСТАН. Вестник науки и образования, (15-1), 106-110.
Муродова Н.А., Юлдашева Ш.X., Жалилова Ф.С., Норова X.У., Жалилов Ф.С. Количественное определение содержания микро- и макроэлементов методом ISP МС в плодах индийского граната. Управлiння якiстю в фармаци: матерiали XIII наук.-практ. конф., м. Харкiв, 17 трав. 2019 р. X.: НФаУ, 2019. C. 180-181.
Самадов, Б. Ш., Мусаева, Д. М., & Дубинина, Н. В. (2019). Сравнительная характеристика и тенденции развития эпидемического процесса гепатита С в Украине и в Узбекистане. Новый день в медицине, (4), 284-290.
Мусаева, Д. М., Самадов, Б. Ш., & Очилова, Г. С. (2020). Гепатопротекторное влияние фенобарбитала при экспериментальном токсическом гепатите. In Лiки-людиш. Сучасш проблеми фармакотерапи i призначення лжарських засобiв: межд. конф.(Харьков, 12-13 марта, 2020) (Vol. 1, pp. 341-344).
Самадов, Б. Ш., & Мусаева, Д. М. (2020). Тенденция развития эпидемического процесса гепатита С в Узбекистане. Матеріали ІV Міжнародної науково-практичної конференції. НФаУ, Харьков. Украина, 430-437.
Мусаева, Д. М., Самадов, Б. Ш., Раджабов, Н. Г., & Шарипова, Р. Г. (2020). Қуритилган анжир меваси тиндирмасининг фармакологик аҳамияти. Новый день в медицине, (2 (30)), 200.
Samadov, B. S., & Dubinina, N. V. (2016). Characteristics and trends of epidemic of hepatitis C in Uzbekistan and Ukraine.
Дубинина, Н. В., Самадов, Б. Ш., Тищенко, И. Ю., Дубініна, Н. В., & Тіщенко, І. Ю. (2020). Вирусные гепатиты с парентеральным механизмом передачи: современные подходы к лечению.
Samadov, B. S., Yaremenko, V. D., & Berezniakova, N. L. (2018). Standartization of active pharmaceutical ingredients in combined dosage form.
Швець, І. О., Самадов, Б. Ш., Ільїна, Т. В., & Ильина, Т. В. (2017). Навчальна практика з фармакогнозії–складова частина професійної підготовки провізора.
Samadov, B., Sych, I. A., Shpychak, T. V., & Kiz, O. V. (2017). Quantitative determination by potentiometric titration method of active pharmaceutical ingredients in complex dosage form.
Дубинина, Н. В., Самадов, Б. Ш., & Тищенко, И. Ю. (2021). Создание вакцин для профилактики и лечения ВИЧ.
Samadov, B. S., Jalilova, F. S., Ziyaeva, D. A., Sharipova, D. S., Ozodova, N. X., Norova, H. U., ... & Kudina, O. V. (2020). Pharmacological properties and chemical composition “Momordica charantia l”.
Мусаева, Д. М., Самадов, Б. Ш., Дубинина, Н. В., Бабаназаров, У. Т., Озодов, Ж. Х. У., Шарипова, Д. Ш., & Озодова, Н. Х. (2020). Антиоксидантная коррекция фармакометаболизирующей функции печени при экспериментальном токсическом гепатите. Вестник науки и образования, (14-1 (92)), 63-70.
Jalilova, F. S. (2022). ANALYSIS OF TRAMADOL IN BIOLOGICAL OBJECTS IN FORENSIC CHEMISTRY PRACTICE. Thematics Journal of Chemistry, 6(1).