SYNTHESIS OF COPOLYMERS BASED ON 1-CHLORO-3-PIPERIDINE-2-PROPYLACRYLATE WITH ACRYLIC ACID AND THEIR PROPERTIES
Keywords:
1-chloro-3-piperidine-2-propylacrylate, acrylic acid, polymer, initiator, kinetic parameters, temperature, antimicrobial activityAbstract
The article presents the results of the copolymerization process of 1-chloro-3-piperidino-2-propylacrylate (XPPA) and acrylic acid (AA). The effect on the copolymerization process of such factors as the nature of the solvent and the ratio of the initial monomers has been studied. The optimal conditions for the synthesis of copolymers under conditions of radical polymerization in the temperature range of 60-80 °C are found. The values of the relative activities of the monomers were calculated by the Fineman-Ross method, which are ????1=0,88, ????2=0,66. The acute toxicity and antimicrobial activity of these synthesized copolymers were studied and it was found that the test compounds according to the parameters of acute toxicity according to the classification of IHS 12.1.007-76 belong to the IV class of low-toxic substances and have an antimicrobial effect against St. Epidermidis, E. coli и Bac. Subtilis.
References
. Панарин, Е.Ф. Полимерные лекарства и биологически активные вещества / Е.Ф. Панарин // Полимеры и медицина. – 2005. – № 1. – С. 20-24.
. Ghorbanloo, M. pH sensitive hydrogel based acrylic acid for controlled drug release / M. Ghorbanloo, A. Heidary // Phys. Chem. Res. – 2017. – V. 5. – № 1. – P. 185-193.
. Каморин Д.М., Ширшин К.В., Орехов Д.В., Сивохин А.П., Садиков А.Ю., Казанцев А.О., Панина Е.А. Радикальная сополимеризatsiя акриловой кислоты и метоксиполиэтиленгликольметакрилата в водном растворе. //Пластические массы. -2017. -№1-2.–С.6-8.
. Прочухан Ю.А., Прочухан К.Ю., Идогова Я.В. Влияние минерализatsiи воды на реологические свойства полимера // Башкирск. химич. журн. – 2014.–Т.21.–№4.–С.80–83.
. Hui H. Thermo- and pH-sensitive dendrimer derivatives with a shell of poly(N,N- dimethylaminoethylmethacrylate) and study of their controlled drug release behavior / H. Hui, F. Xiao-dong, C. Zhong-lin // Polymer. – 2005. - 46. – P. 9514–9522.
. Xaperskaya LS, Medetbekova JM, Sarymzakova R.K. Synthesis of new biologicheski actin so-called on osnove n-zameshchenny gamma-piperidonov // Uspexi sovremennogo estestvoznaniya, 2016. - №9. - p. 38–42.
. Safrokov AP, Terziyan T.V. Acrylic hydrocele acrylic and acrylic acid acetate, initsirovannoe persulfatom ammonia // Vysokomolek. soedinenie. Series B. - 2015. –T. 57. - № 5. - p. 338–345.
J. Jayabharathi, V. Thanikachalam, M. Padamavathy, M. Venkatesh Perumal, J. Fluoresc. 22 (2012) 269-279. https://doi.org/10.1007/s10895-011-0957-5. [9] M. Arockia doss, S. Savithiri, G. Rajarajan, V. Thanikachalam, C. Anbuselvan, Spectrochim. Acta Part A. 151 (2015) 773-784. https://doi.org/10.1016/j.saa.2015. 07.024.
Pulatova N.U., Maksumova O.S. Synthesis of polymers based on 1-chloro-3-piperidine-2-propyl methacrylate // 8 th International conference Science and society -Methods and problems ofpractical application. Vancouver, Canada 2019. -РР. 139 - 141.
Pulatova.N.U., Maksumova.O.S. Piperidine compounds synthesis and properties, ISBN 978-620-4-72608-3, Moldova ”LAP LAMBERT Academik Publishing” 2021.57 P.
Pulatova N.U., Maksumova O.S. Synthesis of esters based on piperidine // The scientific method. 10/Warszava, Poland 2017, 26 - 28 p.
. N.U.Pulatova, O.S. Maksumova, Izabela Barszczewska Rybarek. Synthesis and polymerization processes of 1-chlorine-3- piperidine -2-propylmethacrylate monomer Technical science and innovation: Vol. 2021 : Iss. 3 , Article 4. Available at: https://uzjournals.edu.uz/btstu/vol2021/iss3/4
. Методические указания в Руководстве по экспериментальному (доклиническому) изучению новых фармакологических веществ. Под общей редакцией члена-корреспондента РАМН, профессора Р. У. Хабриева. Издание второе, переработанное и дополненное. -М.:ОАО «Издательство «Медицина», 2005. – 830 с.
. Беленький М.Л. Элементы количественной оценки фармакологического эффекта. Л.: Медгиз, 1963. – 152 с.
. Определение чувствительности микроорганизмов к антимикробным препаратам диско-диффузионным методом (методические указания)» № 012-3/0093, Ташкент, 2007.
. Государственная Фармакопея, XI издание, выпуск 2. Москва: «Медицина», 1990. – С.210-215.
. Государственная Фармакопея РУз, I издание, 2 часть, Ташкент 2021. – С.1451-1453.
