Recent advances on microbial activity of metal complexes: A short review

Abstract

Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Cancer is one of the most fatal diseases, with which millions of people die in unbearable pain every year all over the world. Almost everybody shows extreme fear of cancers and mostly turn pale once mentioning cancers. At the same time, antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research proceed by Md. Kudrat-E-Zahan and et al. over the past few years.