SIGNIFICANCE OF TYPE I COLLAGEN ANTIBODIES IN ISCHAEMIC CARDIOMYOPATHY
Keywords:
ischemic cardiomyopathy, the titer of antibodies to collagen type I, clinical manifestations of the diseaseAbstract
The data of study included the results of 110 men with ischaemic cardiomyopathy (mean age 56.1±1.9 years). All 110 (100%) patients with ischaemic cardiomyopathy were found to have antibodies to type I collagen in their blood. The presence of antibodies was detected by means of test-system of Institute of Immunology and Human Genomics at Academy of Sciences of Republic of Uzbekistan, which is based on enzyme immunoassay method, that helps to identify autoantibodies to collagen type I. In the control group, 38 (95%) participants of the study did not contain these antibodies. Meanwhile, the levels of antibodies to collagen type I varied in patients with ischaemic cardiomyopathy. Depending on antibody titre all patients were divided into two groups: group A comprising 34 (31%) patients with a low level of antibody titre to collagen type I (less than 1:50) and group B with 76 (69%) patients with a high level of antibody titre to collagen type I (more than 1:50). A study of collagen type I antibody levels showed that the higher the level of antibodies, the more severe the manifestations of chronic heart failure, the lower the patients' quality of life and the higher the functional class of angina, while the degree of arterial pressure increase was inversely related.
References
Brooks HL, Lindsey ML. Guidelines for authors and reviewers on antibody use in physiology studies. Am J Physiol Heart Circ Physiol 314: H724 –H732, 2018. doi:10.1152/ajpheart.00512.2017.
O’Donohoe TJ, Schrale RG, Ketheesan N. The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction. Int J Cardiol 209: 226 –233, 2016. doi:10.1016/j.ijcard.2016.02.035.
Carsten Tschöpe, Enrico Ammirati, Biykem Bozkurt. Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nature Reviews Cardiology volume 18, pages169–193 (2021)
Caforio, A. L. P. et al. Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. Eur. Heart J. 38, 2649–2662 (2017).
Bozkurt, B. et al. Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association. Circulation 134, e579–e646 (2016).
Tong Liu, Deli Song, Jianzeng Dong. Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure. Front. Physiol., 24 April 2017 | https://doi.org/10.3389/fphys.2017.00238
Lea Keppner, Margarete Heinrichs, Max Rieckmann. Antibodies aggravate the development of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1358-H1367. doi: 10.1152/ajpheart.00144.2018. Epub 2018 Aug 10.
Trachtenberg, B. H. & Hare, J. M. Inflammatory cardiomyopathic syndromes. Circ. Res. 121, 803–818 (2017).
Shodikulova G.Z. Special features of clinical and functional disorders in patients with undifferentiated connective tissue dysplasia // European science review, 2017. № 3-4. Р. 72-74.
Shodikulova G.Z., Toirov E.S., Babamuradova Z.B. Clinical biochemical features in patients with undifferentiated connective tissue dysplasia // European science review, 2016. № 1. Р.129-131.
Shodikulova G.Z., Ergashova M.M. Features of clinical course early diagnosis of secondary osteoarthritis in women with rheumatoid arthritis. // App. to Journal Therapeutic Bulletin of Uzbekistan. 2021 № 1
Shodikulova G.Z., Shonazarova N.H., Kurbanova Z.P. Features of the clinical course of rheumatoid arthritis in patients with thyroid pathology. // App. to Journal of Biomedicine and Practice of Uzbekistan. 2021, Vol. 6: 256-260
Махмудова А. Н. LEGAL-REGULATORY SYSTEM IN CIVIL SOCIETY CONTROL OF THE PROCESS OF LEGAL SOCIALIZATION OF INDIVIDUALS //ФИЛОСОФИЯ И ЖИЗНЬ МЕЖДУНАРОДНЫЙ ЖУРНАЛ. – 2022. – №. SI-1.
.Nugmanovna M. A. HIGH LEGAL CONSCIOUSNESS AND LEGAL CULTURE-DEVELOPMENT OF OUR COUNTRY //Confrencea. – 2022. – Т. 1. – №. 1.
Nugmanovna M. A. LEGAL SOCIALIZATION OF THE INDIVIDUAL AND LEGAL CULTURE IN MODERN CIVIL SOCIETY:(SOCIO-PHILOSOPHICAL ANALYSIS) //Thematics Journal of Social Sciences. – 2022. – Т. 8. – №. 2.
Nugmanovna M. A., Saodat M. ENSURING THE EFFICIENCY OF PROTECTION OF THE RIGHTS OF MINOR CHILDREN: ON THE EXAMPLE OF FOREIGN EXPERIENCE //British View. – 2022. – Т. 7. – №. 1.
.Nugmanovna M. A. LEGAL SOCIALIZATION OF THE INDIVIDUAL AND LEGAL CULTURE IN MODERN CIVIL SOCIETY:(SOCIO-PHILOSOPHICAL ANALYSIS) //Thematics Journal of Social Sciences. – 2022. – Т. 8. – №. 2.
Nugmanovna M. A. LEGAL EDUCATION AS A MEANS OF FORMING LEGAL CULTURE.
Nugmanovna M. A., Kamariddinovna K. M. WHAT A DOCTOR SHOULD KNOW TO WORK SAFELY AND EFFECTIVELY: INTERNATIONAL NORMS AND RULES //Thematics Journal of Social Sciences. – 2022. – Т. 8. – №. 3.
Nugmanovna M. A. THE NECESSITY OF EDUCATING THE YOUNG GENERATION IN THE SPIRIT OF NATIONAL IDEA IN THE CONTEXT OF GLOBALIZATION //Thematics Journal of Education. – 2022. – Т. 7. – №. 2.
Nugmanovna M. A. et al. Education of tolerance in younger generation //Conferencea. – 2022. – С. 52-55.
Nugmanovna M. A. et al. LEGAL PROTECTION OF DOCTORS IN THE REPUBLIC OF UZBEKISTAN //Conferencea. – 2022. – С. 56-61.
Kamariddinovna K. A., Makhmudova A. N. PROBLEMS OF FORMATION OF TOLERANCE IN SCHOOLCHILDREN IN THE MODERN SCHOOL //Conferencea. – 2022. – С. 112-115
Nugmanovna M. A. et al. EDUCATION OF TOLERANCE IN YOUNGER GENERATION //Conferencea. – 2022. – С. 52-55.
Nugmanovna M. A., Kamariddinovna K. A. Modern biotechnical problems of medicine and their solutions //Archive of Conferences. – 2021. – Т. 13. – №. 1. – С. 169-173.
Nugmanovna M. A. et al. EDUCATION OF TOLERANCE IN YOUNGER GENERATION //Conferencea. – 2022. – С. 52-55.
Kamariddinovna K. A., Nugmanovna M. A. IMPROVING POPULATION HEALTH THE IMPORTANT TASK OF THE STATE //Archive of Conferences. – 2021. – Т. 17. – №. 1. – С. 204-208.
Shokirovna V. S., Nugmanovna M. A. replacing the works of our president Shavkat Mirziyoev in the development of civil society in our country //Archive of Conferences. – 2021. – Т. 17. – №. 1. – С. 200-203.
Yevgeniya M., Nugmanovna M. A. FIGHTING CORRUPTION IN THE REPUBLIC OF UZBEKISTAN //Archive of Conferences. – 2021. – Т. 15. – №. 1. – С. 171-173.
.Nugmanovna M. A. The place and significance of social and legal control in the legal socialization of the individual in civil society //Asian Journal of Research in Social Sciences and Humanities. – 2022. – Т. 12. – №. 2. – С. 21-33.
Nugmanovna M. A. et al. LEGAL PROTECTION OF DOCTORS IN THE REPUBLIC OF UZBEKISTAN //Conferencea. – 2022. – С. 56-61.
Nugmanovna M. A. Action strategy-the basis of a new stage of national development of Uzbekistan //ACADEMICIA: AN INTERNATIONAL MULTIDISCIPLINARY RESEARCH JOURNAL. – 2021. – Т. 11. – №. 1. – С. 774-785.
.Nugmanovna M. A. Legal socialization and individual deviant rights: relationships //falsafa va hayot xalqaro jurnal. – С. 49.
