THE PROBLEM OF THROMBOPHILIA IN CLINICAL PRACTICE. (literature review)
Keywords:
thrombophilia, hemostasis, arterial thrombosis, venous thrombosis, hyperhomocysteinemia, dysfibrinogenemia, antiphospholipid syndromeAbstract
The review presents an analysis of domestic and foreign literature on the significance of the most common forms of thrombophilia in shaping the risk of developing thromboembolic diseases. Modern views on thrombophilias, their significance in the occurrence of arterial and venous thrombosis, and the authors' opinions on the further development of this issue are outlined. The article shows the role of hyperhomocysteinemia, dysfibrinogenemia, antiphospholipid syndrome as a risk factor for the development of thromboembolic complications in cardiovascular diseases.
References
Vardanyan A. V., Badanyan A. L., Mumladze R. B., Patrushev L. I., Dolidze D. D. The use of DNA diagnostics in the treatment tactics of managing patients with deep vein thrombosis. Annals of Surgery, No. 3, 2014, pp. 12-19.
Zhdanova L. V., Patrushev L. I., Dolgikh V. V. Polymorphism of genes responsible for thrombophilia and their influence on the development of thrombosis in childhood. Bulletin of the VSNC SO RAMS , 2013, 4(92). Page 115-118.
Karazhanova L.K., Zhunuspekova A.S. Hyperhomocysteinemia as a risk factor for cardiovascular disease. Science and Health 4, 2016, pp. 129-144.
Kalinin R.E., Suchkov I.A., Rudakova I.N., Nikiforova L.V. Hyperhomocysteinemia and the possibility of its correction in post-thrombotic syndrome of the lower extremities. Bulletin of RUDN University, medicine series, 2016, No. 1, pp. 61-66.
Levashova O.A., Zolkornyaev I.G. Analysis of the level of homocysteine and the prevalence of genetic polymorphism of the folate cycle genes in patients with ischemic stroke. The Journal of scientific articles “Health and Education Millennium”, 2017. Vol. 19. No 1, R. 97-99.
Momot A. P. The problem of thrombophilia in clinical practice // RZhDGiO, 2015, No. 1.
Sanets I.A. ,. Silin A.E., Yarets Yu.I., Anichkin V.V. Genetic markers of venous thromboembolism in surgical patients. News surgery , volume 26, no. 2, 2018, p . 155-162.
AppelmanY, vanRijnBB, TenHaafME, BoersmaE, PetersSA. Sex differences in cardiovascular risk factors and disease prevention // Atherosclerosis, 2015, Vol. 241, pp. 211-218. 9. Ashraf N, Visweshwar N, Jaglal M, Sokol L, Laber D. Evolving paradigm in thrombophilia screening. Blood Coagul Fibrinolysis . 2019;30(5):249–252. doi:10.1097/MBC.
Bounameaux H. ISTH EDUCATIONAL COURSE. Thrombosis and hemorrhage. What are the causes? // Risk factors and pathogenesis of thrombosis. Russia , g . Saint - Petersburg . 2017.
Chiasakul T, De Jesus E, Tong J, et al. Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis. J Am Heart Assoc . 2019;8(19):e012877. doi:10.1161/JAHA.119.012877. 12. Couturaud F, Leroyer C, Tromeur C et al. Factors that predict thrombosis in relatives of patients with venous thromboembolism. Blood. 2014;124(13):2124–2130. 13. Connors J M. Thrombophilia testing and venous thrombosis. N Engl J Med. 2017;377(12):1177–1187.
Garcia-Horton A, Kovacs MJ, Abdulrehman J, Taylor JE, Sharma S, Lazo-Langner A. Impact of thrombophilia screening on venous thromboembolism management practices // Thromb Res, 2017, no. 149, pp. 76-80. 15. Linnemann B, Hart C. Laboratory Diagnostics in Thrombophilia. Hamostaseology . 2019;39(1):49–61. doi:10.1055/s-0039-1677840.
Mahmoodi BK, Cushman M, Anne Næss I, et al. Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies // Circulation, 2017, Vol. 135, no. 1, pp. 7-16. 17. Meroni PL, Tsokos GC. Editorial: Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Front Immunol . 2019;10:199. Published 2019 Feb 25. doi:10.3389/fimmu.2019.00199. 18. Mezhov V, Segan JD, Tran H, Cicuttini FM. Antiphospholipid syndrome: a clinical review. MedJAust . 2019;211(4):184–188. doi:10.5694/mja2.50262. 19. Miyata T, Maruyama K, Banno F, Neki R. Thrombophilia in East Asian countries: are there any genetic differences in these countries? Thromb J 2016; 14 Supple 1:25.
Rallidis L, Gialeraki A, Tsirebolos G, Drosatos A, Katsimardos A, Pavlakis G, Iliodromitis E. Factor V Leiden and prothrombin G20210A mutations in patients with premature myocardial infarction // European Heart Journal, 2017, No. 38 (suppl-1), P. 1735.
Rosendaal FR Causes of venous thrombosis // Thromb J, 2016, No. 14(Suppl 1), P. 24.
Shlebak A. Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis: a case series and a review. J Clin Pathol . 2016;69(4):337–343. doi:10.1136/jclinpath-2015-203077.
Silver RM. Catastrophic antiphospholipid syndrome and pregnancy. Semin Perinatol . 2018;42(1):26–32. doi:10.1053/j.semperi.2017.11.006
Sorigue M, Sarrate E, Morales-Indiano C, Ruiz-Garcia L, Orna E. Applicability of the results of thrombophilia studies in clinical practice. Eur J Intern Med . 2017;39:e27–e28. doi:10.1016/j.ejim.2017.02.022.
Stevens SM. Role of thrombophilia testing: con. J Thromb Thrombolysis . 2015;39(3):379–391. doi:10.1007/s11239-015-1170-1. 26 Suchon P, Resseguier N, Ibrahim M, et al. Common Risk Factors Add to Inherited Thrombophilia to Predict Venous Thromboembolism Risk in Families. TH Open . 2019;3(1):e28–e35. Published 2019 Jan 28. doi:10.1055/s-0039-1677807.