Synthesis of some new aryl substituted chalcones and their antimicrobial study

Abstract

Synthesis and characterization of some new biologically active class of chalcones using a base in ethanol as reaction solvent under mild reaction condition. Chalcones are of great interest due to their use as starting materials in the synthesis of a series of different heterocyclic compounds and the precursors of all flavonoids are chalcones with oxygenated function on the aromatic rings. Structures of the newly synthesized compounds were confirmed by spectroscopic methods and newly synthesized compounds were studies for bioactivity (antibacterial and antifungal) by using Micrococcus caseolyticus, Bacillus subtilis and two gram negative bacteria viz., Escherichia coli, Pseudomonas putida, Aspergillus niger, Rhizopus oryzae and Aspergillus flavus. 1a-1d reported strong antimicrobial activity in this current study against all the bacteria used. 1a-1c have shown high potency especially against A.niger, A. flavus and Rhizopus oryzae.